Polygenic prediction and GWAS of depression, PTSD, and suicidal ideation/self-harm in a Peruvian cohort

Genome-wide approaches including polygenic risk scores (PRSs) are now widely used in medical research; however, few studies have been conducted in low- and middle-income countries (LMICs), especially in South America. This study was designed to test the transferability of psychiatric PRSs to individuals with different ancestral and cultural backgrounds and to provide genome-wide association study (GWAS) results for psychiatric outcomes in this sample. The PrOMIS cohort (N = 3308) was recruited from prenatal care clinics at the Instituto Nacional Materno Perinatal (INMP) in Lima, Peru. Three major psychiatric outcomes (depression, PTSD, and suicidal ideation and/or self-harm) were scored by interviewers using valid Spanish questionnaires. Illumina Multi-Ethnic Global chip was used for genotyping. Standard procedures for PRSs and GWAS were used along with extra steps to rule out confounding due to ancestry. Depression PRSs significantly predicted depression, PTSD, and suicidal ideation/self-harm and explained up to 0.6% of phenotypic variation (minimum p = 3.9 × 10−6). The associations were robust to sensitivity analyses using more homogeneous subgroups of participants and alternative choices of principal components. Successful polygenic prediction of three psychiatric phenotypes in this Peruvian cohort suggests that genetic influences on depression, PTSD, and suicidal ideation/self-harm are at least partially shared across global populations. These PRS and GWAS results from this large Peruvian cohort advance genetic research (and the potential for improved treatments) for diverse global populations. 

Fabricação digital na América do Sul: um mapeamento de linhas de ação a partir da arquitetura e urbanismo

The article presents a mapping of digital fabrication laboratories in South America from the architecture and urbanism field. First, it draws a brief context of implementation of facilities and growing of expertise highlighting economic, academic and cultural aspects. Second, it presents some data mapped from 31 laboratories of the region, as infrastructure, and correlations between uses and applications. Third, it organizes the mapped laboratories in two significant approaches for the region’s context: works focused on technological development and actions directed to the social and environmental development. Fourth, it infers some possible steps of the field in the region in the near future.

Autor(es): Sperling, David M.; Herrera Polo, Pablo C.; Celani, Gabriela; Scheeren, Rodrigo

Editorial: Blucher Design Proceedings

Revista: Blucher Design Proceedings

ISSN: 2318-6968

Fecha de publicación: Noviembre 2015

URL: http://hdl.handle.net/10757/604633

DOI: http://dx.doi.org/10.5151/despro-sigradi2015-30212

PDF: Full Text